keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 523.00 | |
25 mg | 8-10 weeks | $ 1,620.00 | |
50 mg | 8-10 weeks | $ 2,110.00 | |
100 mg | 8-10 weeks | $ 3,270.00 |
Description | TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities. |
Targets&IC50 | Thyroid hormone β:22 nM, THRα:36 nM |
In vitro | TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50 s of 36 and 22 nM for TRα and TRβ, respectively[1]. |
In vivo | In the cholesterol-fed rat model, treatment with TR antagonist 1 reduces heart rate and shows a tendency to increase the proportion of low-density lipoprotein cholesterol (LDL-C) to a certain extent [1]. |
Molecular Weight | 561.26 |
Formula | C25H23Br2NO4 |
CAS No. | 500794-88-7 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (89.13 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TR antagonist 1 500794-88-7 Endocrinology/Hormones Thyroid hormone receptor(THR) inhibitor inhibit