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TGN-020

Catalog No. T5102 CAS 51987-99-6

Synonyms: TGN020

TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.

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TGN-020, CAS 51987-99-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.
Targets&IC50	AQP4:3.1 μM

Synonyms	TGN020
Molecular Weight	206.22
Formula	C8H6N4OS
CAS No.	51987-99-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 8 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huber VJ, et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7. 2. Igarashi H, et al. Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport. 2013 Apr 17;24(6):324-8.

Citations

1. Guo S, Song Z, He J, et al. Akt/aquaporin-4 signaling aggravates neuropathic pain by activating astrocytes after spinal nerve ligation in rats. Neuroscience. 2021

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Bioactive Compound Library

Related Products

Related compounds with same targets

AER-271 TGN-020 TC-AQP1-1 p-Tolylmaleimide DFP00173

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TGN-020 51987-99-6 离子通道 Aquaporin scar edema glial Inhibitor TGN 020 TGN020 AQP4 Aquaporin 4 inhibit PROTAC Linkers inhibitor

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