Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TES-991 is a potent and selective inhibitor of human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)(IC50 of 3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 523.00 | |
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 514.00 |
Description | TES-991 is a potent and selective inhibitor of human α Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD)(IC50 of 3 nM). |
Targets&IC50 | ACMSD (human):3 nM |
In vitro | TES-991 significantly increase intracellular NAD+ levels, providing further proof of their mechanism of action. TES-991 exhibits an inhibition of cytochrome P450 2C19, suggesting a possible involvement of the 2H-tetrazole motif. |
In vivo | TES-991(intravenous,0.5 mg/kg) shows low blood clearance, with low volumes of distribution and halflives (t1/2) of about 4.0 and 5.0 h, respectively, although after oral administration at 5 mg/kg, the blood concentrations of TES-991 is quantifiable for up to 8 h. A moderate systemic exposure is observed for the 2H-tetrazole analogue, TES-991, a good systemic exposure is recorded for the free acid. |
Molecular Weight | 393.45 |
Formula | C17H11N7OS2 |
CAS No. | 1883602-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 62.5 mg/mL (158.85 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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