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TAT-DEF-Elk-1 TFA (1220751-16-5 free base)

Catalog No. TP2157L CAS TP2157L

Synonyms: TDE TFA, TAT-DEF-Elk-1 TFA

TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity

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TAT-DEF-Elk-1 TFA (1220751-16-5 free base) Chemical Structure

TAT-DEF-Elk-1 TFA (1220751-16-5 free base), CAS TP2157L

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Description	TAT-DEF-Elk-1 TFA is a cell-penetrating peptide Elk-1 inhibitor, mimics and specifically interferes with the DEF domain of Elk-1. TAT-DEF-Elk-1 blocks Elk-1 phosphorylation and prevents Elk-1 nuclear translocation without interfering with ERK nor MSK1 activation. TAT-DEF-Elk-1 is a useful tool to analyze the role of Elk-1 in this process during the development of neuronal plasticity
Targets&IC50	ELK1:
In vitro	Elk-1 phosphorylation on Ser383/389 has a dual function and triggers both Elk-1 nuclear translocation and SRE-dependent gene expression. TAT-DEF-Elk-1 (5 μM; 2 hours) treatment shows significant inhibition of c-Fos, Zif268, and JunB, but has no effects on c-Jun expression. TAT-DEF-Elk-1 (5-10 μM; 1 hour) specifically inhibits glutamate-induced elk-1 activation and does not interfere with ERK, MSK-1, or CREB phosphorylation [1].
In vivo	TAT-DEF-Elk-1 (i.p.; 1mg/kg; daily; 14 days) reflects antidepressant efficacy in mice, it decreases immobility similar to the antidepressant desipramine and fluoxetine [2].

Synonyms	TDE TFA, TAT-DEF-Elk-1 TFA
Molecular Weight	3675.09
Formula	C157H260N57F3O42
CAS No.	TP2157L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lavaur J, et al. A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics.J Neurosci. 2007 Dec 26;27(52):14448-58. 2. Apazoglou K, et al. Antidepressive effects of targeting ELK-1 signal transduction.Nat Med. 2018 May;24(5):591-597.

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Keywords

TAT-DEF-Elk-1 TFA (1220751-16-5 free base) TP2157L Others TAT DEF Elk 1 TFA (1220751 16 5 free base) TDE TFA 1220751-16-5 free base TATDEFElk1 TFA (1220751165 free base) TAT-DEF-Elk-1 TFA 1220751-16-5 inhibitor inhibit

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