Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS-114 is a dual inhibitor of dUTPase/dihydropyrimidine dehydrogenase (DPD), and can improving the therapeutic efficacy of fluoropyrimidine.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 118.00 | |
25 mg | 8-10 weeks | $ 671.00 | |
50 mg | 8-10 weeks | $ 872.00 | |
100 mg | 8-10 weeks | $ 1,310.00 |
Description | TAS-114 is a dual inhibitor of dUTPase/dihydropyrimidine dehydrogenase (DPD), and can improving the therapeutic efficacy of fluoropyrimidine. |
In vitro | the cytotoxicity of 5-Fluorouracil (5-FU) increased by TAS-114 (1-10 μM; 72 hours) and 5-FU,2′-deoxy-5-fluorouridine (FdUrd) against various cancer cell lines in dose-dependent manner. |
In vivo | In mice, the antitumor activity of 5-FU when co-administers with Capecitabine (539 mg/kg/day) increased by TAS-114 (37.5-1,200 mg/kg/day; orally; 1-14 days) . |
Molecular Weight | 451.54 |
Formula | C21H29N3O6S |
CAS No. | 1198221-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (221.46 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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TAS-114 1198221-21-4 Others TAS 114 TAS114 inhibitor inhibit