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Syk Inhibitor II

Catalog No. T4348   CAS 726695-51-8

Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).

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Syk Inhibitor II Chemical Structure
Syk Inhibitor II, CAS 726695-51-8
Pack Size Availability Price/USD Quantity
2 mg 5 days $ 40.00
1 mL * 10 mM (in DMSO) 5 days $ 86.00
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Purity: 98.52%
Purity: 97.63%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
Targets&IC50 Syk:41 nM
In vitro In mice,Syk inhibitor II prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro (IC50 = 460 nM) and inhibits passive cutaneous anaphylaxis reactions (ID50 = 13.2 mg/kg, s.c.).
Molecular Weight 340.3
Formula C14H15F3N6O
CAS No. 726695-51-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL

H2O: 25 mg/mL

TargetMolReferences and Literature

1. Hisamichi H,etal.Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives.Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Inhibitor Library Anti-Parkinson's Disease Compound Library Neurotransmitter Receptor Compound Library

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Related compounds with same targets
RS102895 hydrochloride H-9 dihydrochloride Nuciferine FFN246 Trazodone Tropanserin PRX933 hydrochloride rac Desmethyl Citalopram Hydrochloride

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Keywords

Syk Inhibitor II 726695-51-8 Angiogenesis GPCR/G Protein Neuroscience Tyrosine Kinase/Adaptors 5-HT Receptor Syk ATP-competitive Serotonin Receptor antigen inhibit Spleen tyrosine kinase Anti-allergic pyrimidine-carboxamide Inhibitor 5-hydroxytryptamine Receptor inhibitor

 

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