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Suprofen

Catalog No. T6687   CAS 40828-46-4
Synonyms: Maldocil, Suprol, TN-762, Profenal

Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

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Suprofen Chemical Structure
Suprofen, CAS 40828-46-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 35.00
10 mg In stock $ 59.00
25 mg In stock $ 113.00
50 mg In stock $ 198.00
100 mg In stock $ 372.00
500 mg In stock $ 896.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 99.17%
Purity: 99.14%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Suprofen (Suprol) is an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.
In vitro Suprofen inactivates the diclofenac-4-hydroxylase activity of baculovirus-expressed P450 2C9 in a time- and concentration-dependent manner, which is consistent with mechanism-based inactivation. [1] Suprofen is a known generator of singlet oxygen whose participation in the reaction is supported by the effects of quenchers and scavengers. Suprofen photosensitizes the production of alkali-labile cleavage sites in DNA much more efficiently than direct strand breaks. [2] Suprofen sensitizes photo-oxidation of cholesterol, producing 7 alpha- and 7 beta-hydroperoxides but not 5 alpha-hydroperoxide of cholesterol. Suprofen-sensitized photo-oxidation of membrane lipids of liposomes increases leakage of trapped glucose, suggesting photosensitized destabilization of the membrane structure. [3] Suprofen incorporation in the phosphatidylcholine (PC) evaporation vesicles (REV) membrane leads to approximately 5% increase in the encapsulation efficiency (34%) in comparison to standard REV (29%). [4]
In vivo Suprofen combined with PGF2 alpha blocks induction of uterine contractions, suggesting the possibility that Suprofen also antagonizes PGF2 alpha receptor binding. [5] Suprofen are effective at preventing BAB disruption after paracentesis in dogs, indicating their potential usefulness for treatment of prostaglandin-mediated ocular disease. [6] Suprofen (3.7 mg/kg, i.v.) induces a marked decrease in the firing evoked in arthritic rats by ankle mobilization. [7]
Synonyms Maldocil, Suprol, TN-762, Profenal
Molecular Weight 260.31
Formula C14H12O3S
CAS No. 40828-46-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 48 mg/mL(184.4 mM)

TargetMolReferences and Literature

1. O'Donnell JP, et al. Drug Metab Dispos, 2003, 31(11), 1369-1377. 2. Starrs SM, et al. Photochem Photobiol, 2000, 72(3), 291-297. 3. Fujita H, et al. Photodermatol Photoimmunol Photomed, 11992-11993, 9(5), 203-208. 4. Cirli OO, et al. J Control Release, 2004, 96(1), 85-96. 5. Hahn DW, et al. Prostaglandins, 1982, 23(1), 1-16.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Anti-Prostate Cancer Compound Library Anti-Fibrosis Compound Library Anti-Colorectal Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library

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Keywords

Suprofen 40828-46-4 Immunology/Inflammation Neuroscience COX PGE Synthase Maldocil inhibit TN 762 Suprol TN762 TN-762 Prostaglandin E synthase PGE synthase Profenal Inhibitor inhibitor

 

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