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Sunitinib-d10

Catalog No. T13039 CAS 1126721-82-1

Synonyms: Sunitinib D10, SU 11248 D10

Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for <a href="/target/VEGFR" style="display: inline; color: #c13a36">VEGFR</a>2 and <a href="/target/PDGFR" style="display: inline; color: #c13a36">PDGFR</a>β, respectively).

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Sunitinib-d10, CAS 1126721-82-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively).
Targets&IC50	PDGFRβ:2 nM, VEGFR2:80 nM

Synonyms	Sunitinib D10, SU 11248 D10
Molecular Weight	408.54
Formula	C22H27FN4O2
CAS No.	1126721-82-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46(7):1116-9. 2. Ali MM, et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 2011 Mar 2;30(5):894-905.

Related Products

Related compounds with same targets

AC710 SU14813 maleate Imatinib impurities3 CT52923 Dovitinib (TKI258) Lactate ZM323881 hydrochloride Toceranib Sunitinib-d10

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sunitinib-d10 1126721-82-1 Angiogenesis Tyrosine Kinase/Adaptors PDGFR VEGFR Sunitinib-d-10 Sunitinib D10 SU 11248 D10 Sunitinibd10 Inhibitor inhibitor inhibit

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