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Succinyl phosphonate

Catalog No. T13020 CAS 26647-82-5

Succinyl phosphonate is a α-ketoglutarate dehydrogenase inhibitor .

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Succinyl phosphonate, CAS 26647-82-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Succinyl phosphonate is a α-ketoglutarate dehydrogenase inhibitor .

In vitro

Succinyl phosphonate(0.01 mM) completely inhibits isolated brain KGDHC even in the presence of a 200-fold higher concentration of its substrate. In cultured human fibroblasts, 0.01 mM succinyl phosphonate produced 70% inhibition of α-ketoglutarate dehydrogenase complex. DESP and TESP are also inhibitory in the cell system, but only after preincubation, suggesting the release of their charged groups by cellular esterases[2]. Succinyl phosphonate inhibits 2-Oxoglutarate dehydrogenase , the first rate-limiting component of the mitochondrial multi-enzyme complex of oxidative decarboxylation of 2-oxoglutarate, in a highly selective and efficient manner[3].

Molecular Weight	182.07
Formula	C4H7O6P
CAS No.	26647-82-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (274.62 mM)

References and Literature

1. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70. 2. Bunik VI, et al. Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutaratedehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 2005 Aug 9;44(31):10552-61. 3. Bunik VI, et al. Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget. 2016 May 3;7(18):26400-21.

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Succinyl phosphonate 26647-82-5 Others inhibitor inhibit

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