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Sitaxsentan

Catalog No. T12924 CAS 184036-34-8

Synonyms: TBC-11251, IPI 1040

Sitaxsentan (TBC-11251) is A selective endothelin A (ETA) receptor antagonist. Endothelin is an effective vasoconstrictor. Sitaxsentan blocks the binding of endothelin to its receptors, thereby eliminating the harmful effects of endothelin.

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Sitaxsentan, CAS 184036-34-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 91.00
5 mg	In stock	$ 211.00
10 mg	In stock	$ 346.00
25 mg	In stock	$ 537.00
50 mg	In stock	$ 727.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00
1 mL * 10 mM (in DMSO)	In stock	$ 249.00

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Purity: 99.34%

Purity: 97.99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	TBC-11251, IPI 1040
Molecular Weight	454.9
Formula	C18H15ClN2O6S2
CAS No.	184036-34-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.55 mg/mL (10 mM)

References and Literature

1. Marcus Chin, et al.Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy.Can Respir J. 2012 Jan-Feb;19(1):e1-2. 2. Sandoval J, et al. STRIDE-4 investigators.Safety and efficacy of sitaxsentan 50 and 100 mg in patients with pulmonary arterial hypertension.Pulm Pharmacol Ther. 2012 Feb;25(1):33-9. Epub 2011 Nov 2. 3. Safdar Z. Effect of transition from sitaxsentan to ambrisentan in pulmonary arterial hypertension.Vasc Health Risk Manag. 2011;7:119-24. Epub 2011 Mar 2. 4. Rondelet B, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension.Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1118-23. Epub 2010 Aug 6. 5. Kaehler, et al. Successful treatment of portopulmonary hypertension with the selective endothelin receptor antagonist Sitaxentan. Wien Klin Wochenschr. 2011 Apr;123(7-8):248-52. Epub 2011 Mar 31.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Clinical Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Aminaftone BQ-788 SB-209670 BMS 182874 hydrochloride Ro 46-2005 Darusentan BQ-3020 ammonium Patecibart

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sitaxsentan 184036-34-8 GPCR/G Protein Endothelin Receptor IPI1040 TBC-11251 IPI 1040 IPI-1040 TBC11251 TBC 11251 inhibitor inhibit

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