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Safranal

Catalog No. TN2423   CAS 116-26-7

Safranal is the special volatile aroma compound of saffron.Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.

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Safranal Chemical Structure
Safranal, CAS 116-26-7
Pack Size Availability Price/USD Quantity
500 mg In stock $ 41.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 96.33%
Purity: 94.09%
Purity: 90.66%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Safranal is the special volatile aroma compound of saffron.Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.
In vitro At first, the potential toxic effect of safranal on OLN-93 viability was evaluated. Also, the cells were pretreated with safranal (0.1, 1, 10, 50, 100 and 200 μM) for 2 h and then subjected to glutamic acid (16 mM) or quinolinic acid (8 mM) toxicity for 24 h, in which the same treatments were applied. Results: Safranal at concentration ranges of 1-800 μM had no toxic effect on cell viability (p>0.05). Treatment with safranal significantly increased cell viability following glutamic acid or quinolinic acid insults at concentrations higher than 1 μM (p<0.01). The cytoprotective potential of safranal was also accompanied by decreased ROS accumulation (p<0.001) and malondialdehyde level (p<0.001) following glutamic acid or quinolinic acid insults. The data suggests that safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters.
In vivo Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[2].
Source
Molecular Weight 150.22
Formula C10H14O
CAS No. 116-26-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (665.69 mM), sonification is recommended.

Ethanol: 100 mg/mL (665.69 mM), sonification is recommended.

TargetMolReferences and Literature

1. Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury 2. Peeraphong Lertnimitphun, et al. Safranal Alleviates Dextran Sulfate Sodium-Induced Colitis and Suppresses Macrophage-Mediated Inflammation. Front Pharmacol. 2019 Nov 1;10:1281.

Related compound libraries

This product is contained In the following compound libraries:
Tobacco Monomer Library Miao medicine Compound Library NO PAINS Compound Library Terpene Natural Product Library Human Endogenous Metabolite Compound Library Plus PBCRBS Traditional Chinese Medicine Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Natural Product Library Human Metabolite Library Covalent Inhibitor Library

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Keywords

Safranal 116-26-7 oxidation-reduction Antioxidant disease inhibit anti-inflammatory Saffron Inhibitor Parkinson’s neuroprotective orally inhibitor

 

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