Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 67.00 | |
5 mg | 5 days | $ 116.00 | |
10 mg | 5 days | $ 175.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 128.00 |
Description | SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). |
Targets&IC50 | Sepiapterin reductase:74 nM |
In vitro | SPR inhibitor 3 obviously decreases SPR activity in mouse primary cultures of sensory neurons (IC50=0.45 μM) without affecting the activity of the GTP cyclohydroxylase 1 enzyme [1]. |
Synonyms | SPRi3 |
Molecular Weight | 262.3 |
Formula | C14H18N2O3 |
CAS No. | 1292285-54-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SPR inhibitor 3 1292285-54-1 Others SPRi3 inhibitor inhibit