Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral inhibitor of metalloendopeptidase (NEP), with antihypertensive effect. |
In vitro | in vitro,SCH 42495 selectively inhibits hydrolysis of leu-enkephalin and ANF with IC50 of 8.3 and 10.0 nM, respectively[1]. |
In vivo | Significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days caused by SCH 42495 (30 mg/kg; oral gavage; twice daily). Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2]. SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1]. |
Synonyms | SCH 42495 (racemate) |
Molecular Weight | 411.58 |
Formula | C20H29NO4S2 |
CAS No. | 145841-10-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SCH 42495 racemate 145841-10-7 Others SCH42495 racemate SCH 42495 SCH-42495 SCH 42495 (racemate) inhibitor inhibit