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Ranirestat

Catalog No. T16723 CAS 147254-64-6

Synonyms: AS-3201

Ranirestat effective and orally active aldose reductase inhibitor ( IC50s: 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively and a Ki: 0.38 nM for recombinant human AR). Ranirestat has a neuroprotective effect on diabetic retinas.

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Ranirestat, CAS 147254-64-6

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 691.00
50 mg	8-10 weeks	$ 898.00
100 mg	8-10 weeks	$ 1,440.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ranirestat effective and orally active aldose reductase inhibitor ( IC50s: 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively and a Ki: 0.38 nM for recombinant human AR). Ranirestat has a neuroprotective effect on diabetic retinas.
Targets&IC50	Aldose reductase (rat lens):11 nM, Aldose reductase (human recombinant):（ki）0.38 nM, Aldose reductase (human recombinant):15 nM
In vitro	The potency of Ranirestat inhibition of sorbitol accumulation is similar between rat erythrocytes and sciatic nerves (IC50: 0.010 μM and 0.041 μM, respectively). Ranirestat concentration-dependently inhibits sorbitol accumulation in rat erythrocytes and sciatic nerves incubated in the high concentration (500 mg/dl) of glucose [1].
In vivo	Ranirestat also improves the STZ-induced decrease in motor nerve conduction velocity (MNCV) in a dose-dependent manner. Ranirestat (0.03-1.0 mg/kg;p.o.; once daily; for 3 weeks; male STD-Wistar rats) treatment dose-dependently reduces the elevated sorbitol and fructose levels in the rat sciatic nerves without affecting blood glucose level [1].

Synonyms	AS-3201
Molecular Weight	420.19
Formula	C17H11BrFN3O4
CAS No.	147254-64-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (118.99 mM)

References and Literature

1. Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10. 2. Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ranirestat 147254-64-6 Others AS 3201 AS-3201 AS3201 inhibitor inhibit

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