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RU-SKI 43 hydrochloride

Catalog No. T12797L CAS 1782573-67-4

RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat)(IC50 of 850 nM), has anti-cancer activity.

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RU-SKI 43 hydrochloride Chemical Structure

RU-SKI 43 hydrochloride, CAS 1782573-67-4

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 73.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat)(IC50 of 850 nM), has anti-cancer activity.
Targets&IC50	Hhat:850 nM
In vivo	After IV administration,RU-SKI 43 hydrochloride has a t1/2 of 17 min in mouse plasma[1].

Molecular Weight	423.01
Formula	C22H31ClN2O2S
CAS No.	1782573-67-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 51 mg/mL (120.56 mM)

H2O: 2.5 mg/mL (5.91 mM), Sonication is recommended.

References and Literature

1. Petrova E, et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.Nat Chem Biol. 2013 Apr;9(4):247-9. 2. Petrova E, et al. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.575.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RU-SKI 43 hydrochloride 1782573-67-4 Others RUSKI 43 hydrochloride RU SKI 43 hydrochloride RU-SKI 43 Hydrochloride inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.