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RJW100

Catalog No. T38680 CAS 1276664-20-0

RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

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RJW100, CAS 1276664-20-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 665.00
5 mg	In stock	$ 1,390.00
10 mg	In stock	$ 1,890.00
25 mg	In stock	$ 2,830.00
50 mg	In stock	$ 3,820.00
100 mg	In stock	$ 5,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,590.00

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Purity: 99.15%

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Description

In vitro

RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 µM. RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 µM. Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 µM) binding[1]. RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins[2].

Molecular Weight	386.57
Formula	C28H34O
CAS No.	1276664-20-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (142.27 mM)

References and Literature

1. Richard J Whitby, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14;54(7):2266-81. 2. Yuxia Zhang, et al. Regulation of miR-200c by nuclear receptors PPARα, LRH-1 and SHP. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):135-9.

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Keywords

RJW100 1276664-20-0 Others RJW 100 RJW-100 inhibitor inhibit

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