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RAGE antagonist peptide acetate

Catalog No. TP1935L1 CAS TP1935L1

RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflammatory activities. RAGE antagonist peptide acetate prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4.

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RAGE antagonist peptide acetate Chemical Structure

RAGE antagonist peptide acetate, CAS TP1935L1

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1 mg	In stock	$ 85.00
5 mg	In stock	$ 248.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 626.00
50 mg	In stock	$ 892.00
100 mg	In stock	$ 1,220.00

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Description	RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflammatory activities. RAGE antagonist peptide acetate prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4.
In vitro	In cancer cells, RAGE antagonist peptide acetate reduces the ability of the ligands to stimulate RAGE activation of NFκB[2].
In vivo	In mice bearing asthma, RAGE antagonist peptide acetate (RAP; 4 mg/kg; i.p.) blunts airway reactivity, airway inflammation and goblet cell metaplasia, and decreases release of Th2 cytokines. RAGE antagonist peptide acetate also reduces total, cytoplasmic and nuclear levels of β-catenin, enhanced β-catenin phosphorylation at Ser33/37/Thr41, which triggers ubiquitination, down-regulated expression of β-catenin targeted genes, and tends to keep β-catenin at the cytomembrane, shifting β-catenin from a signalling active pattern to an adhesive function[1]. RAGE antagonist peptide acetate reduces the growth and metastasis of pancreatic tumors and also inhibited glioma tumor growth. RAGE antagonist peptide acetate (100 μg) inhibits RAGE-mediated Basal NFκB Activity in PDAC cells in vivo[2].

Molecular Weight	1332.61
Formula	C59H105N13O19S
CAS No.	TP1935L1

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173(17):2600-13. 2. Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18(16):4356-64.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Peptide Compound Library Anti-Cancer Compound Library Neuronal Signaling Compound Library

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Keywords

RAGE antagonist peptide acetate TP1935L1 Neuroscience Beta Amyloid RAGE antagonist peptide Acetate inhibitor inhibit

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