Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections. Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections and attenuates Ebola virus transmission.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 29.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Pyronaridine tetraphosphate is an orally active, mannitol-containing inhibitor of DNA topoisomerase 2 and erythrocyte cytokine with antimalarial and antitumour activity.Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections. Pyronaridine tetraphosphate treats P. falciparum and Echinococcus granulosus infections and attenuates Ebola virus transmission. |
Targets&IC50 | P. falciparum:1.53-3.94 nM |
In vitro | With an IC50 value of 1.53-3.94 nM, pyronaridine tetraphosphate (24 h) exhibits anti-P. falciparum activity[2]. |
In vivo | Reducing the parasitic burden in Echinococcus granulosus-infected mice, pyronaridine tetraphosphate (57 mg/kg, oral administration, q.d. for 30 days) has been demonstrated[1].Reducing the parasitic burden in secondarily infected (cysts) mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, q.d. for 3 days) has shown efficacy[1].Exhibiting a higher exposure in the liver than in the plasma in male ICR mice, pyronaridine tetraphosphate (57 mg/kg, intraperitoneal injection, for a single dose) has been observed[1]. |
Molecular Weight | 910.03 |
Formula | C29H44ClN5O18P4 |
CAS No. | 76748-86-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (21.98 mM), Sonication is recommended.
DMSO: 10 mg/mL (10.99 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Pyronaridine tetraphosphate 76748-86-2 DNA Damage/DNA Repair Topoisomerase Pyronaridine inhibitor inhibit