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Pritelivir mesylate hydrate

Catalog No. T16575 CAS 1428321-10-1

Synonyms: BAY 57-1293 mesylate hydrate, AIC316 mesylate hydrate

Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.

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Pritelivir mesylate hydrate Chemical Structure

Pritelivir mesylate hydrate, CAS 1428321-10-1

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5 mg	5 days	$ 39.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection.
Targets&IC50	HSV1-2:0.02 μM
In vivo	Pritelivir mesylate hydrate is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex. Pritelivir mesylate hydrate has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis. Pritelivir mesylate hydrate (0.03-45 mg/kg) significantly increases survival. Pritelivir mesylate hydrate (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Combination therapies of Pritelivir mesylate hydrate at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS [2][3].

Synonyms	BAY 57-1293 mesylate hydrate, AIC316 mesylate hydrate
Molecular Weight	516.61
Formula	C19H24N4O7S3
CAS No.	1428321-10-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ligat G, et al. Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-PrimaseComplex. Front Microbiol. 2018 Oct 23;9:2483. 2. Wald A, et al. Helicase-primase inhibitor Pritelivir for HSV-2 infection. N Engl J Med. 2014 Jan 16;370(3):201-10. 3. Quenelle DC, et al. Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis. Antiviral Res. 2018 Jan;149:1-6.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pritelivir mesylate hydrate 1428321-10-1 Others BAY 57-1293 mesylate hydrate AIC316 mesylate hydrate AIC316 mesylate Hydrate Pritelivir mesylate Hydrate BAY 57-1293 mesylate Hydrate inhibitor inhibit

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