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Pramiconazole

Catalog No. T25982 CAS 219923-85-0

Synonyms: R-126638, R126638, R 126638, Azoline

Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis.

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Pramiconazole, CAS 219923-85-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 543.00
5 mg	In stock	$ 1,210.00
10 mg	In stock	$ 1,630.00
25 mg	In stock	$ 2,390.00
50 mg	In stock	$ 3,260.00
100 mg	In stock	$ 4,380.00

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Purity: 98.84%

ee: 100%

Purity: 98.34%

ee: 100%

Biological Description

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Description

Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis.

In vivo

This study was performed in 2 groups of subjects suffering from seborrheic dermatitis. The first group (n = 17) remained untreated and was used as a control. Clinical, mycological, and metrological assessments were performed at inclusion and during the following 2 weeks. The second group of subjects (n = 10) received a single 200-mg oral dose of pramiconazole at inclusion. Clinical, mycological, and bio-metrological evaluations were performed before and during 1 month following the single antifungal intake. For both parts of the study, several parameters were assessed including yeast density, desquamation, erythema, itching, and sebum excretion. Results: In the control group, no significant changes were observed in any of the parameters during the observation period. The findings were markedly different in the pramiconazole-treated subjects. The yeast density was significantly improved on days 3, 7, and 28. Desquamation, erythema, itching, and the global clinical evaluation as assessed by the patients and investigators significantly improved on days 7 and 28. A trend in the decrease of scaliness was noted. No effect on sebum excretion was evidenced. In conclusion, a single 200-mg dose of pramiconazole exhibits in vivo efficacy in controlling some important clinical aspects of seborrheic dermatitis. Following a reduction in the number of yeasts on day 3, a decrease in the severity of clinical signs and symptoms occurred from day 7 onwards. Sebum excretion appeared uninvolved in the clearing process of seborrheic dermatitis. A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis. The density in Malassezia present on lesional skin is first decreased, followed by clearing of the clinical signs.[3]

Synonyms	R-126638, R126638, R 126638, Azoline
Molecular Weight	659.73
Formula	C35H39F2N7O4
CAS No.	219923-85-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Geria AN, et al. Pramiconazole, a triazole compound for the treatment of fungal infections. IDrugs. 2008;11(9):661-670. 2. Ausma J, et al. Absence of an active metabolite for the triazole antifungal pramiconazole. Acta Derm Venereol. 2007;87(1):22-26. 3. Piérard GE, et al. A pilot study on seborrheic dermatitis using pramiconazole as a potent oral anti-Malassezia agent. Dermatology. 2007;214(2):162-169. 4. Faergemann J, et al. A double-blind, randomized, placebo-controlled, dose-finding study of oral pramiconazole in the treatment of pityriasis versicolor. J Am Acad Dermatol. 2009;61(6):971-976. 5. Donders G, et al. Efficacy of a single oral dose of 200 mg pramiconazole in vulvovaginal yeast infections: an exploratory phase IIa trial. Acta Derm Venereol. 2008;88(5):462-466.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Pramiconazole 219923-85-0 Microbiology/Virology Antifungal R-126638 R126638 R 126638 Azoline inhibitor inhibit

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