Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 50.00 | |
10 mg | In stock | $ 70.00 | |
25 mg | In stock | $ 114.00 | |
50 mg | In stock | $ 167.00 | |
100 mg | In stock | $ 248.00 | |
500 mg | In stock | $ 535.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 72.00 |
Description | Pentabromophenol (NSC-5717) suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors. |
In vitro | Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40 μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration, ATP-linked respiration, maximum respiration, basal glycolytic and compensatory glycolysis were altered by Pentabromophenol. Phagocytosis was decreased for Pentabromophenol and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to visualize aggregate formation. Pentabromophenol, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger[1]. |
Synonyms | NSC 5717, NSC5717, NSC-5717 |
Molecular Weight | 488.59 |
Formula | C6HBr5O |
CAS No. | 608-71-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.89 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Pentabromophenol 608-71-9 Stem Cells TGF-beta/Smad NSC 5717 NSC5717 NSC-5717 inhibitor inhibit