Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective, and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant (Ki: 0.24 nM).
Pack Size | Availability | Price/USD | Quantity |
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5 mg | Inquiry | $ 468.00 |
Description | PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective, and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant (Ki: 0.24 nM). |
In vitro | PPACK covalently binds to the specific active-site Ser of thrombin and cross-links with His57 at the binding site forming a tetrahedral PPACK-thrombin complex. The complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. PPACK is currently being investigated as an anti-coagulant to prevent blood coagulation. Study results show that PPACK is able to dose-dependently inhibit thrombin-induced platelet accumulation. |
Synonyms | PPACK Dihydrochloride |
Molecular Weight | 523.88 |
Formula | C21H31ClN6O3·2HCl |
CAS No. | T23177 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HCL: Soluble
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PPACK Dihydrochloride (71142-71-7 free base) T23177 Others PPACK Dihydrochloride (71142717 free base) 71142-71-7 PPACK Dihydrochloride (71142 71 7 free base) PPACK Dihydrochloride PPACK 71142-71-7 free base inhibitor inhibit