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PNU288034

Catalog No. T12512 CAS 383199-88-0

PNU288034 is a potent oxazolidinone antibiotic with antimicrobial activity for the prevention and treatment of Gramnegative infections.

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PNU288034, CAS 383199-88-0

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 700.00
5 mg	In stock	$ 1,800.00

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Purity: 98.41%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PNU288034 is a potent oxazolidinone antibiotic with antimicrobial activity for the prevention and treatment of Gramnegative infections.
In vitro	In vitro studies, conducted to characterize the involved transporters, demonstrate uptake of PNU-288034 by human organic anion transporter 3 (OAT3; Km = 44 +/- 5 μM) and human multidrug and toxin extrusion protein 1 (hMATE1; Km = 340 +/- 55 μM)[1].
In vivo	In liver microsomes across species, PNU-288034 exhibits metabolic stability, and the unchanged drug is cleared in the urine through an apparent active renal secretion process in rat and monkey. Coadministration of PNU-288034 with the OAT3 inhibitor probenecid significantly increases the plasma area under the curve (170%) and reduces both plasma and renal clearance in monkey. Furthermore, coadministration of PNU-288034 with cimetidine also reduces plasma clearance in rats to a rate comparable to probenecid coadministration[1].

Molecular Weight	403.4
Formula	C16H19F2N3O5S
CAS No.	383199-88-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lai Y, et al. Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1). J Pharmacol Exp Ther. 2010 Sep 1;334(3):936-44.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PNU288034 383199-88-0 Microbiology/Virology Antifungal PNU-288034 PNU 288034 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.