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PBP2

Catalog No. T33894 CAS T33894

Synonyms: PBP-2, PBP 2

PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells.

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PBP2, CAS T33894

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells.

Synonyms	PBP-2, PBP 2
Molecular Weight	804.92
Formula	C40H48N14O5
CAS No.	T33894

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Lange F, Pfennigwerth N, Höfken LM, Gatermann SG, Kaase M. Characterization of mutations in Escherichia coli PBP2 leading to increased carbapenem MICs. J Antimicrob Chemother. 2018 Nov 27. doi: 10.1093/jac/dky476. [Epub ahead of print] PubMed PMID: 30496417. 2. Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. PLoS Genet. 2018 Oct 18;14(10):e1007726. doi: 10.1371/journal.pgen.1007726. eCollection 2018 Oct. PubMed PMID: 30335755; PubMed Central PMCID: PMC6207328. 3. Thakur SD, Levett PN, Horsman GB, Dillon JR. Association of Neisseria gonorrhoeae genogroups and specific PBP2/MtrR/PorB mutation patterns with susceptibility to penicillin in a susceptible gonococcal population. J Antimicrob Chemother. 2018 Oct 1;73(10):2682-2686. doi: 10.1093/jac/dky233. PubMed PMID: 29992304. 4. Ábrók M, Lázár A, Szécsényi M, Deák J, Urbán E. Combination of MALDI-TOF MS and PBP2' latex agglutination assay for rapid MRSA detection. J Microbiol Methods. 2018 Jan;144:122-124. doi: 10.1016/j.mimet.2017.11.021. Epub 2017 Nov 24. PubMed PMID: 29180272.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PBP2 T33894 PBP-2 PBP 2 inhibitor inhibit

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