Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 288.00 | |
50 mg | In stock | $ 478.00 | |
100 mg | In stock | $ 689.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes . |
Targets&IC50 | JARID1A:6 μM, JARID1C:4.9 μM, JARID1B:3 μM |
In vitro | PBIT, which inhibits JARID1B with an IC50 of about 3 μm in vitro.?Consistent with this, PBIT treatment inhibited removal of H3K4me3 by JARID1B in cells.?Furthermore, this compound inhibited proliferation of cells expressing higher levels of JARID1B. |
Molecular Weight | 241.31 |
Formula | C14H11NOS |
CAS No. | 2514-30-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (414.40 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PBIT 2514-30-9 Chromatin/Epigenetic Histone Methyltransferase Histone Demethylase Inhibitor inhibit inhibitor