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Osajin

Catalog No. T16407 CAS 482-53-1

Synonyms: NSC 21565, CID 95168

Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.

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Osajin, CAS 482-53-1

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5 mg	Inquiry	$ 649.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Osajin is the major bioactive iso avone present in the fruit of Maclura pomifera. It has antitumor, antioxidant, and anti-inflammatory activities.
In vitro	Osajin shows growth inhibitory activity on six human cancer cell lines, including kidney, lung, prostate, breast, melanoma and colon cancer cells. Osajin obviously reduces the viability of human NPC cells in a dose-dependent manner. Osajin causes apoptosis in human NPC cells through multiple apoptotic pathways, including the extrinsic death receptor pathway, and intrinsic pathways relying on mitochondria and endoplasmic reticulum stress[1][2].
In vivo	The cardioprotective effects of osajin and pomiferin are attributed to their ability to suppress oxidative stress, coinciding with enhanced ventricular function. These compounds mitigate myocardial dysfunction induced by ischemia-reperfusion, evidenced by elevated levels of antioxidant enzymes and overall antioxidant activity[3].

Synonyms	NSC 21565, CID 95168
Molecular Weight	404.46
Formula	C25H24O5
CAS No.	482-53-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Huang TT, et al. Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin. PLoS One. 2011 Apr 12;6(4):e18308. 2. Son IH, et al. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5. 3. Florian T, et al. Effects of prenylated isoflavones osajin and pomiferin in premedication on heart ischemia-reperfusion. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):93-100.

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Keywords

Osajin 482-53-1 Others CID-95168 NSC21565 NSC 21565 NSC-21565 CID 95168 CID95168 inhibitor inhibit

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