Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ONO-8590580 is a negative allosteric modulator of GABAA α5.
Description | ONO-8590580 is a negative allosteric modulator of GABAA α5. |
In vivo | The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice. |
Synonyms | CS-2894 |
Molecular Weight | 376.43 |
Formula | C21H21FN6 |
CAS No. | 1802661-73-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 60 mg/mL (159.39 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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