Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 60.00 | |
2 mg | In stock | $ 85.00 | |
5 mg | In stock | $ 128.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 396.00 | |
50 mg | In stock | $ 592.00 | |
100 mg | In stock | $ 845.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 143.00 |
Description | ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5. |
In vivo | The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data shows that ONO-8590580 is a novel GABAA α5 NAM that enhances hippocampal memory function without an anxiogenic or proconvulsant risk. |
Synonyms | CS-2894 |
Molecular Weight | 376.43 |
Formula | C21H21FN6 |
CAS No. | 1802661-73-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (159.39 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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ONO-8590580 1802661-73-9 Membrane transporter/Ion channel Neuroscience GABA Receptor CS-2894 γ-Aminobutyric acid Receptor Inhibitor Gamma-aminobutyric acid Receptor CS 2894 ONO 8590580 inhibit CS2894 ONO8590580 inhibitor