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ONO-8590580
🥰Excellent
Catalog No. TQ0040Cas No. 1802661-73-9
Alias CS-2894
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
ONO-8590580
🥰Excellent
Purity: 99.43%
Catalog No. TQ0040Alias CS-2894Cas No. 1802661-73-9
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $60 | In Stock | |
| 2 mg | $85 | In Stock | |
| 5 mg | $128 | In Stock | |
| 10 mg | $178 | In Stock | |
| 25 mg | $396 | In Stock | |
| 50 mg | $592 | In Stock | |
| 100 mg | $845 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock |
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Purity:99.43%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5. |
| In vivo | The study investigates the effects of ONO-8590580 on MK-801/scopolamine-induced cognitive deficits using the 8-arm radial maze test, with doses of MK-801 and scopolamine at 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.), respectively. ONO-8590580 (20 mg/kg, p.o.) significantly reduces errors and total latency compared to the control. Unlike donepezil, ONO-8590580 significantly decreases the number of errors, suggesting it may be more effective for treating AD patients. The data indicate that ONO-8590580 is a novel GABAA α5 NAM that enhances hippocampal memory function without causing anxiogenic or proconvulsant effects. |
| Alias | CS-2894 |
| Molecular Weight | 376.43 |
| Formula | C21H21FN6 |
| Cas No. | 1802661-73-9 |
| Smiles | Cc1c(F)c(Nc2ccc(cn2)-c2cn(C)cn2)cc2n(CC3CC3)cnc12 |
| Relative Density. | 1.39 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (159.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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