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ONO-8590580

Catalog No. TQ0040 CAS 1802661-73-9

Synonyms: CS-2894

ONO-8590580 is a negative allosteric modulator of GABAA α5.

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ONO-8590580, CAS 1802661-73-9

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Purity 98%

Biological Description

Chemical Properties

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Description

ONO-8590580 is a negative allosteric modulator of GABAA α5.

In vivo

The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice.

Synonyms	CS-2894
Molecular Weight	376.43
Formula	C21H21FN6
CAS No.	1802661-73-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 60 mg/mL (159.39 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Kawaharada S, et al. ONO-8590580, a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. J Pharmacol Exp Ther. 2018 Jul;366(1):58-65.

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