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Norethindrone

Norethindrone
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Purity:99.55%
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Norethindrone

Catalog No. T1514Cas No. 68-22-4
Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
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Pack SizePriceAvailabilityQuantity
50 mg$38In Stock
100 mg$53In Stock
200 mg$63In Stock
500 mg$81In Stock
1 mL x 10 Mm (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
In vitro
Norethisterone, or, is a 19-nortestosterone derivative, that lacks a C19 methyl group and possesses C17 ethinyl substitution, and primarily displays progestational activity rather than androgenic activity and, to a lesser extent, has oestrogenic and anti-oestrogenic activity. [1] NET shows five- to eight-fold weaker progesterone receptor binding and transactivation activities than the Org 2058 (100%) and two-fold stronger than progesterone. Binding and transactivation activities of NET for androgen receptor (5α-dihydrotestosterone 100%) are 3.2 and 1.1%, respectively, for estrogen receptor none (estradiol 100%) and for glucocorticoid receptor below 1% (dexamethasone 100%). [2] Norethisterone (1 nM) inhibits serum-stimulated or oestradiol (0.1 nM)-induced proliferation of MCF-7 by 41% and 34%, respectively. [3] Norethisterone (50 nM) induces signi?cant effects on rat osteoblast proliferation, differentiation, and mineralization processes, mimicking the effects of estradiol, which is mediated by estrogen receptor. [4]
Cell Research
96 well plates are seeded with approximately 1000 MCF-7 cells per well in assay kit medium. Subsequently, the cells are incubated with medium containing charcoal/dextran treated serum for three days. The Norethisterone is then added alone to the wells and incubated for seven days. To mimic continuous combined HRT the cells are treated with an oestradiol (0.1 nM)/ Norethisterone combination for seven days. After incubation for seven days, cell proliferation is measured by using an ATP-chemosensitivity test. In brief, proliferation is quantified by measuring light emitted during the bioluminescence reaction of luciferine in the presence of ATP and luciferase.(Only for Reference)
AliasNorethisterone
Chemical Properties
Molecular Weight298.42
FormulaC20H26O2
Cas No.68-22-4
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 20 mg/mL (67.02 mM)
Ethanol: 5 mg/mL (16.75 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.3510 mL16.7549 mL33.5098 mL167.5491 mL
5 mM0.6702 mL3.3510 mL6.7020 mL33.5098 mL
10 mM0.3351 mL1.6755 mL3.3510 mL16.7549 mL
DMSO
1mg5mg10mg50mg
20 mM0.1675 mL0.8377 mL1.6755 mL8.3775 mL
50 mM0.0670 mL0.3351 mL0.6702 mL3.3510 mL
100 mM0.0335 mL0.1675 mL0.3351 mL1.6755 mL

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