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NAAD sodium salt

Catalog No. T33565 CAS 104809-30-5

Synonyms: NAAD Na salt, Deamido Nad Sodium Salt, NAAD Na, NaAD

NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.

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NAAD sodium salt, CAS 104809-30-5

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Biological Description

Chemical Properties

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Description	NAAD sodium salt (NAAD Na salt) is a substrate of nicotinamide adenine dinucleotide synthase and can be used in studies about the specificity and kinetics of the substrate.
In vitro	NAAD sodium salt, produced in the biosynthesis of NAD+ from tryptophan and NA2, was elevated from less than 20 nM to as high as 0.91 μM in peripheral blood mononuclear cells[3].
In vivo	In mice, after the administration of nicotinic acid (500 mg/kg; i.p.), NAAD sodium salt is observed in kidneys, ovaries, lung, heart, and brain while after the administration of radioactive nicotinamide (500 mg/kg; i.p.), NAAD sodium salt is only in mouse liver[3].

Synonyms	NAAD Na salt, Deamido Nad Sodium Salt, NAAD Na, NaAD
Molecular Weight	686.4
Formula	C21H25N6NaO15P2
CAS No.	104809-30-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29. 2. Patel S, et al. Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand. Biochem J. 2000 Dec 15;352 Pt 3:725-9. 3. Samuel A J Trammell, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948. 4. Ralf Jauch, et al. Structures of Escherichia coli NAD synthetase with substrates and products reveal mechanistic rearrangements. J Biol Chem. 2005 Apr 15;280(15):15131-40.

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Keywords

NAAD sodium salt 104809-30-5 inhibit Inhibitor Endogenous Metabolite NAAD NAAD Na NAAD sodium mononucleotide NAAD Na salt nicotinate NAD+ Deamido Nad Sodium Salt NAAD Na, NaAD adenylyltransferases Deamido nad synthetase inhibitor

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