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N-Desethyl Sunitinib

Catalog No. T12145 CAS 356068-97-8

Synonyms: SU-11662

N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.

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N-Desethyl Sunitinib, CAS 356068-97-8

Pack Size	Availability	Price/USD	Quantity
2 mg	5 days	$ 77.00
1 mL * 10 mM (in DMSO)	5 days	$ 152.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
In vitro	Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner[1].Sunitinib also potently inhibits Kit and FLT-3[3].
In vivo	Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model[1].

Synonyms	SU-11662
Molecular Weight	370.42
Formula	C20H23FN4O2
CAS No.	356068-97-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (134.98 mM), Sonification is recommended.

References and Literature

1. O'Farrell AM, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003 May 1;101(9):3597-605. Epub 2003 Jan 16. 2. Mendel DB, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Can 3. Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor r

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Desethyl Sunitinib 356068-97-8 Angiogenesis Tyrosine Kinase/Adaptors VEGFR c-Kit PDGFR N Desethyl Sunitinib SU-11662 NDesethyl Sunitinib Inhibitor SU11662 SU 12662 inhibit SU-12662 SU12662 SU 11662 inhibitor

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