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N-Desethyl Sunitinib

N-Desethyl Sunitinib
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N-Desethyl Sunitinib

Catalog No. T12145Cas No. 356068-97-8
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$775 days
1 mL x 10 mM (in DMSO)$1527-10 days
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Product Introduction

Bioactivity
Description
N-Desethyl Sunitinib (SU-11662) is a sunitinib metabolite.
In vitro
Sunitinib inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM, respectively. Sunitinib inhibits the proliferation of MV4;11 and OC1-AML5 cells with IC50 of 8 nM and 14 nM, respectively, and induces apoptosis in a dose-dependent manner[1].Sunitinib also potently inhibits Kit and FLT-3[3].
In vivo
Sunitinib treatment (20 mg/kg/day) dramatically suppresses the growth subcutaneous MV4;11 (FLT3-ITD) xenografts and prolongs survival in the FLT3-ITD bone marrow engraftment model[1].
AliasSU-11662
Chemical Properties
Molecular Weight370.42
FormulaC20H23FN4O2
Cas No.356068-97-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 50 mg/mL (134.98 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6996 mL13.4982 mL26.9964 mL134.9819 mL
5 mM0.5399 mL2.6996 mL5.3993 mL26.9964 mL
10 mM0.2700 mL1.3498 mL2.6996 mL13.4982 mL
20 mM0.1350 mL0.6749 mL1.3498 mL6.7491 mL
50 mM0.0540 mL0.2700 mL0.5399 mL2.6996 mL
100 mM0.0270 mL0.1350 mL0.2700 mL1.3498 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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