This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Myelin Basic Protein (MBP) (68-82), guinea pig
Catalog No. TP1092 CAS
98474-59-0
Synonyms:
MBP (68-82), guinea pig
Myelin Basic Protein (MBP) (68-82), guinea pig is a peptide with the sequence Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn.Myelin Basic Protein (MBP) (68-82), guinea pig(MBP (68-82), guinea pig) is a fragment of myelin basic protein (MBP).
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Myelin Basic Protein (MBP) (68-82), guinea pig, CAS 98474-59-0
Myelin Basic Protein (MBP) (68-82), guinea pig is a peptide with the sequence Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn.Myelin Basic Protein (MBP) (68-82), guinea pig(MBP (68-82), guinea pig) is a fragment of myelin basic protein (MBP).
In vitro
Multiple sclerosis is the most common autoimmune disorder affecting the central nervous system. The whole blood samples are analyzed for activation capacity and the activatability of CD4+ and CD8+ T-lymphocytes by human total myelin basic protein (MBP), human MBP 104-118 fragment, and guinea pig MBP (68-82) fragment in this study. A significant increase in the number of activated T-lymphocytes was observed in the whole blood. For all three tested MBPs, this increase in activated CD4+ and CD8+ T-lymphocytes is statistically significant (p<0.01). However, this increase in activated T-cells is most prominent following incubation with human total MBP, followed by human 104-118 fragment; the smallest increase is observed following incubation with guinea pig MBP (68-82) fragment (human total MBP>huMBP-104-118>guinea pig MBP (68-82))[1].
In vivo
This study investigates the impact of preemptive bee venom acupuncture (BVA) treatment, starting from the day of myelin basic protein (MBP) (68-82) immunization, on the onset and progression of experimental autoimmune encephalomyelitis (EAE) and associated weight loss. After immunization, rats in the MBP group began showing early signs of EAE, such as partial loss of tail tone, within 5-9 days, progressing to more severe neurological symptoms, including various degrees of limb paralysis, between 10-16 days. In contrast, rats treated with BVA exhibited milder neurological impairments, with a dose-dependent reduction in symptom severity and delayed onset of symptoms (BVA 0.8 mg/kg, 6.4±0.6 days) observed 11-15 days post-immunization. Additionally, the maximum clinical score was significantly lower in the BVA-treated groups (BVA 0.25 mg/kg, 3.7±0.2; BVA 0.8 mg/kg, 2.8±0.3) compared to the untreated MBP group. Moreover, while the MBP group's mean body weight decreased, the MBP + BVA group's mean body weight significantly increased compared to the MBP-only group, highlighting a potential protective effect of BVA against EAE-induced weight loss and symptom severity.
Synonyms
MBP (68-82), guinea pig
Molecular Weight
1736.79
Formula
C71H113N23O28
CAS No.
98474-59-0
Storage
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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