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Mitonafide

Catalog No. T25817 CAS 54824-17-8

Synonyms: NSC-300288, NSC300288, NSC 300288

Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.

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Mitonafide, CAS 54824-17-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 40.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 198.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 537.00
200 mg	In stock	$ 767.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 76.00

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Purity: 99.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Mitonafide (NSC-300288) suppresses the activity of M. tuberculosis NAD+ dependent DNA ligase A. Mitonafide is a DNA intercalating agent.

Synonyms	NSC-300288, NSC300288, NSC 300288
Molecular Weight	313.31
Formula	C16H15N3O4
CAS No.	54824-17-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13 mg/ml (41.49 mM)

References and Literature

1. Korycka-Machala M, et al. Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli. Molecules. 2017 Jan 17;22(1). pii: E154. 2. Kumar A, et al. Solvent free, catalyst free, microwave or grinding assisted synthesis of bis-cyclic imide derivatives and their evaluation for anticancer activity. Bioorg Med Chem Lett. 2017 Feb 1;27(3):501-504. 3. Johnson CA, et al. Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes. Bioorg Med Chem. 2015 Jul 1;23(13):3586-91. 4. Machado KE, et al. Apoptotic events induced by maleimides on human acute leukemia cell lines. Chem Res Toxicol. 2013 Dec 16;26(12):1904-16.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Human Metabolite Library ReFRAME Related Library Anti-Bacterial Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mitonafide 54824-17-8 Microbiology/Virology Antibacterial NSC-300288 NSC300288 NSC 300288 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.