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Methoxychlor

Catalog No. T5627 CAS 72-43-5

Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca2 homeostasis and cell viability in different cell models.

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Methoxychlor, CAS 72-43-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 37.00
10 mg	In stock	$ 50.00
25 mg	In stock	$ 68.00
50 mg	In stock	$ 116.00
100 mg	In stock	$ 173.00
200 mg	In stock	$ 261.00
500 mg	In stock	$ 497.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 98.95%

Purity: 98.82%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca2 homeostasis and cell viability in different cell models.
In vitro	In HA59T cells, methoxychlor induced a [Ca2?]i rise by inducing Ca2? entry via protein kinase C-sensitive Ca2?-permeable channels, without causing Ca2? release from stores. Methoxychlor also induced apoptosis that was independent of [Ca2?]i rises.
Cell Research	Fura-2, a Ca2?-sensitive fluorescent dye, was applied to measure [Ca2?]i. Methoxychlor at concentrations of 0.1-1 μM caused a [Ca2?]i rise in a concentration-dependent manner. Removal of external Ca2? abolished methoxychlor's effect. Methoxychlor-induced Ca2? influx was confirmed by Mn2?-induced quench of fura-2 fluorescence. Methoxychlor-induced Ca2? entry was inhibited by nifedipine, econazole, SK&F96365, and protein kinase C modulators. Methoxychlor killed cells at concentrations of 10-130 μM in a concentration-dependent fashion. Chelation of cytosolic Ca2? with 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent methoxychlor's cytotoxicity. Methoxychlor (10 and 50 μM) induced apoptosis concentration-dependently as determined by using Annexin V/propidium iodide staining

Molecular Weight	345.65
Formula	C16H15Cl3O2
CAS No.	72-43-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (65.1 mM)

References and Literature

1. Horng C T , Chou C T , Tseng H W , et al. Effect of Methoxychlor on Ca²⁺ Homeostasis and Apoptosis in HA59T Human Hepatoma Cells[J]. Chin J Physiol, 2015, 58(1):1-8.

Related compound libraries

This product is contained In the following compound libraries：

Human Metabolite Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Methoxychlor 72-43-5 Others inhibitor inhibit

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