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Merbarone

Catalog No. T28017 CAS 97534-21-9

Synonyms: RLBN-1001, NSC-336628, RLBN1001, NSC336628

Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix. Merbarone induces apoptosis in CEM cells through activation of ICE/CED-3-like protease.

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Merbarone, CAS 97534-21-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	RLBN-1001, NSC-336628, RLBN1001, NSC336628
Molecular Weight	263.27
Formula	C11H9N3O3S
CAS No.	97534-21-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Spallarossa A, Rotolo C, Sissi C, Marson G, Greco ML, Ranise A, La Colla P, Busonera B, Loddo R. Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents. Bioorg Med Chem. 2013 Nov 1;21(21):6328-36. doi: 10.1016/j.bmc.2013.08.056. PubMed PMID: 24063907. 2. Pastor N, Domínguez I, Orta ML, Campanella C, Mateos S, Cortés F. The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. Mutat Res. 2012 Oct-Nov;738-739:45-51. doi: 10.1016/j.mrfmmm.2012.07.005. PubMed PMID: 22921906. 3. Attia SM. Dominant lethal mutations of topoisomerase II inhibitors etoposide and merbarone in male mice: a mechanistic study. Arch Toxicol. 2012 May;86(5):725-31. doi: 10.1007/s00204-011-0799-6. PubMed PMID: 22207148. 4. Wang L, Roy SK, Eastmond DA. Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells. Mutat Res. 2007 Mar 1;616(1-2):70-82. PubMed PMID: 17174356.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Merbarone 97534-21-9 RLBN 1001 RLBN-1001 NSC-336628 RLBN1001 NSC 336628 NSC336628 inhibitor inhibit

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