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MSI-1436 lactate

Catalog No. T12117 CAS 1309370-86-2

Synonyms: Trodusquemine lactate, Aminosterol-1436 lactate

MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

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MSI-1436 lactate, CAS 1309370-86-2

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 946.00
10 mg	Inquiry	$ 1,590.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MSI-1436 lactate is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)
Targets&IC50	PTB1B:1 μM , TCPTP:224 μM
In vitro	Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].
In vivo	Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].

Synonyms	Trodusquemine lactate, Aminosterol-1436 lactate
Molecular Weight	1000.17
Formula	C37H72N4O5S.7/2C3H6O3
CAS No.	1309370-86-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 33.33 mg/mL (33.32 mM)

DMSO: 54 mg/mL (53.99 mM), Sonication and heating are recommended.

References and Literature

1. Lantz KA, et al. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-1523. 2. Qin Z, et al. Chronic stress induces anxiety via an amygdalar intracellular cascade that impairs endocannabinoid signaling. Neuron. 2015 Mar 18;85(6):1319-31. 3. Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MSI-1436 lactate 1309370-86-2 Others MSI1436 lactate Trodusquemine lactate MSI 1436 lactate MSI-1436 Lactate MSI1436 Lactate Aminosterol-1436 Lactate Aminosterol-1436 lactate MSI 1436 Lactate Trodusquemine Lactate inhibitor inhibit

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