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Cell Cycle/Checkpoint CDK MSC2530818

MSC2530818

Catalog No. TQ0266   CAS 1883423-59-3
Purity 99.33% Datasheet

MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).

MSC2530818, CAS 1883423-59-3
Pack Size Availability Price/USD Quantity
5 mg In stock 165.00
10 mg In stock 280.00
25 mg In stock 595.00
50 mg In stock 1020.00
100 mg In stock 1760.00
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Purity 98.00%
Purity 99.33%
Biological Description
Chemical Properties
Storage & Solubility Information
Description MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).
Targets&IC50
Animal Research
MSC2530818 is assessed in an established SW620 human colorectal cancer xenograft model in female NCr athymic mice. Tumor-bearing mice are treated orally with MSC2530818 (50 mg/kg bid or 100 mg/kg qd) for 16 days. Tumor weights are measured and body weights are monitored [1].
Appearance solid
Molecular Weight 340.81
Formula C18H17ClN4O
CAS No. 1883423-59-3

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

:

DMSO: 120 mg/mL (352.1 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Czodrowski P, et al. Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. J Med Chem. 2016 Oct 27;59(20):9337-9349.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.