Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lycobetaine acetate (Oxylycorine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Ungeremine have strong antibacterial activity against Flavobacterium columnare
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 81.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 192.00 | |
50 mg | In stock | $ 283.00 | |
100 mg | In stock | $ 418.00 |
Description | Lycobetaine acetate (Oxylycorine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Ungeremine have strong antibacterial activity against Flavobacterium columnare |
In vitro | Ungeremine displayed cytotoxic activity towards the 9 cancer cell lines tested, including drug-sensitive and MDR phenotypes. The IC50values obtained varied from 3.67 μM (in MDA-MB-231-BCRP breast carcinoma cells) to 75.24 μM (against in CEM/ADR5000 leukemia cells) for ungeremine and from 0.02 μM (against CCRF-CEM cells) to 122.96 μM (against CEM/ADR5000 cells) for doxorubicin (control drug). Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1]. |
Cell Research | The cytotoxicity, ferroptotic and necroptotic cell death were determined by the resazurin reduction assay. Caspase activation was evaluated using the caspase-Glo assay. Flow cytometry was applied for the analysis of cell cycle analysis (PI staining), apoptosis (annexin V/PI staining), mitochondrial membrane potential (MMP) (JC-1) and reactive oxygen species (ROS) (H2DCFH-DA). Apoptotic, necroptotic and autophagic markers were determined by Western blotting. CCRF-CEM leukemia cells were used for all mechanistic studies[1]. |
Source |
Synonyms | Oxylycorine |
Molecular Weight | 325.32 |
Formula | C18H15NO5 |
CAS No. | 61221-41-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: Insoluble
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Lycobetaine acetate 61221-41-8 Others Lycobetaine Acetate Oxylycorine inhibitor inhibit