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Lucigenin

Catalog No. T19023 CAS 2315-97-1

Synonyms: NSC-151912, L-6868

Lucigenin (NSC-151912) (L-6868) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells.

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Lucigenin, CAS 2315-97-1

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 30.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 99.42%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Lucigenin (NSC-151912) (L-6868) is a chemiluminescent probe used to indicate the presence of endogenously generated superoxide anion radicals in cells.

In vitro

Upon single-electron reduction of Lucigenin by a radical species the subsequent form of Lucigenin presents amplified chemiluminescence which is measurable and can be correlated to the respective amount of reactive radical species present in the system. In addition to indicating the presence of radicals in cells, Lucigenin shows interaction with redox-active oxidoreductase enzymes. Lucigenin is shown to mediate the reduction of cytochrome C by xanthine oxidase and to increase the rate of NADPH oxidation.

Synonyms	NSC-151912, L-6868
Molecular Weight	510.5
Formula	C28H22N4O6
CAS No.	2315-97-1

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80mg/mL (156.71 mM)

References and Literature

1. Li Y, et al. Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J Biol Chem. 1998 Jan 23;273(4):2015-23. 2. Rost M, et al. What do we measure with luminol-, lucigenin- and penicillin-amplified chemiluminescence? 1. Investigations with hydrogen peroxide and sodium hypochlorite. J Biolumin Chemilumin. 1998 Nov-Dec;13(6):355-63.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lucigenin 2315-97-1 Others NSC-151912 inhibit NSC 151912 L-6868 L 6868 NSC151912 Inhibitor L6868 inhibitor

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