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Leachianone A

Catalog No. TN1856 CAS 97938-31-3

Synonyms: Isokurarinone

Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.

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Leachianone A, CAS 97938-31-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 128.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 339.00

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Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
Targets&IC50	HepG2 cells:3.4microg/ml
In vitro	In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1]
In vivo	Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1].
Source	Natural Products > Fabaceae > Sophora

Synonyms	Isokurarinone
Molecular Weight	438.51
Formula	C26H30O6
CAS No.	97938-31-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 75 mg/ml (171.03 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cheung CS, et al. Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells. Cancer Lett. 2007 Aug 18;253(2):224-35. Epub 2007 Mar 26. 2. Jeong GS, et al. Lavandulyl flavanones from Sophora flavescens protect mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1. Biol Pharm Bull. 2008 Oct;31(10):1964-7.

Related compound libraries

This product is contained In the following compound libraries：

Selected Plant-Sourced Compound Library Natural Product Library for HTS Flavonoid Natural Product Library Glutamine Metabolism Compound Library

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Related compounds with same targets

Sergliflozin A SGLT inhibitor-1 SGL5213 Licogliflozin Picraline LY2794193 IRAK inhibitor 4 trans HSK0935

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Leachianone A 97938-31-3 GPCR/G Protein SGLT Apoptosis Inhibitor inhibit Isokurarinone inhibitor

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