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Leachianone A

Catalog No. TN1856 CAS 97938-31-3

Synonyms: Isokurarinone

Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.

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Leachianone A, CAS 97938-31-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 128.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 793.00
50 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 339.00

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Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Leachianone A (Isokurarinone) is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
Targets&IC50	HepG2 cells:3.4microg/ml
In vitro	In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1]
In vivo	Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1].
Source	Natural Products > Fabaceae > Sophora

Synonyms	Isokurarinone
Molecular Weight	438.51
Formula	C26H30O6
CAS No.	97938-31-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 75 mg/ml (171.03 mM)

References and Literature

1. Cheung CS, et al. Leachianone A as a potential anti-cancer drug by induction of apoptosis in human hepatoma HepG2 cells. Cancer Lett. 2007 Aug 18;253(2):224-35. Epub 2007 Mar 26. 2. Jeong GS, et al. Lavandulyl flavanones from Sophora flavescens protect mouse hippocampal cells against glutamate-induced neurotoxicity via the induction of heme oxygenase-1. Biol Pharm Bull. 2008 Oct;31(10):1964-7.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Flavonoid Natural Product Library Glutamine Metabolism Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Leachianone A 97938-31-3 GPCR/G Protein SGLT Apoptosis Isokurarinone Inhibitor inhibit inhibitor

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