Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 128.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,080.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 339.00 |
Description | Leachianone A is a potential antitoxic agent, it shows inhibitory effects on cadmium- Induced cytotoxicity. |
Targets&IC50 | HepG2 cells:3.4microg/ml |
In vitro | In this study, Leachianone A, isolated from Radix Sophorae, possessed a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment. Its action mechanism via induction of apoptosis involved both extrinsic and intrinsic pathways. Its anti-tumor effect was further demonstrated in vivo by 17-54% reduction of tumor size in HepG2-bearing nude mice, in which no toxicity to the heart and liver tissues was observed[1] |
In vivo | Intravenous injection of 20 mg/kg and 30 mg/kg Leachianone A once daily for 30 days significantly reduced tumor volume in LA-treated nude mice by 17-54% compared to nude mice given vehicle alone[1]. |
Source |
Synonyms | Isokurarinone |
Molecular Weight | 438.51 |
Formula | C26H30O6 |
CAS No. | 97938-31-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 75 mg/ml (171.03 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Leachianone A 97938-31-3 GPCR/G Protein SGLT Apoptosis Inhibitor inhibit Isokurarinone inhibitor