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L-Glutathione reduced

Catalog No. T1085 CAS 70-18-8

Synonyms: GSH, Isethion, Glutathione, γ-L-Glutamyl-L-cysteinyl-glycine, Glutathion, Tathion

L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutathione reduced is a cofactor for certain enzymes and is involved in the rearrangement of protein disulfide bonds and the reduction of peroxides.

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L-Glutathione reduced Chemical Structure

L-Glutathione reduced, CAS 70-18-8

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Purity: 99.19%

Purity: 98.72%

Purity: 97.37%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	L-Glutathione reduced (Glutathione) is a naturally occurring tripeptide found in cells as an endogenous antioxidant that scavenges oxygen free radicals. L-Glutathione reduced is a cofactor for certain enzymes and is involved in the rearrangement of protein disulfide bonds and the reduction of peroxides.
In vitro	METHODS: NSCs cells were treated with L-Glutathione reduced (0.5 mM) and sevoflurane (3%) for 24 h. Apoptosis was detected using TUNEL staining. RESULTS: Supplementation with reduced L-Glutathione reduced the effect of sevoflurane on apoptosis of NSCs. [1]
In vivo	METHODS: To study in vivo activity, L-Glutathione reduced (100 mg/kg) was administered orally to mice and GSH concentrations were measured in plasma at 30, 45, and 60 min, and in the liver, kidneys, heart, lungs, brain, small intestine, and skin 1 h later. RESULTS: Within 30 min of oral L-Glutathione reduced administration, plasma GSH concentrations increased from 30 µM to 75 µM, consistent with a rapid flow of GSH from the intestinal lumen to the plasma. Under these conditions of GSH sufficiency, GSH concentrations in most tissues did not exceed control values over the same time course, with the exception of lung. [2]

Synonyms	GSH, Isethion, Glutathione, γ-L-Glutamyl-L-cysteinyl-glycine, Glutathion, Tathion
Molecular Weight	307.32
Formula	C10H17N3O6S
CAS No.	70-18-8

Storage

keep away from direct sunlight,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble, The compound is unstable in solution. Please use soon.

H2O: 153.7 mg/mL (500 mM)

References and Literature

1. Fan P, et al. Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway. Metab Brain Dis. 2023 Aug;38(6):2037-2053. 2. Aw TY, et al. Oral glutathione increases tissue glutathione in vivo. Chem Biol Interact. 1991;80(1):89-97.

Citations

1. Fan P, Lu Y, Wei H, et al.Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.Metabolic Brain Disease.2023: 1-17. 2. Liu Y, Wang Z, Jin H, et al.Squalene-epoxidase-catalyzed 24 (S), 25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity.Cell Reports.2024, 43(4).

Related compound libraries

This product is contained In the following compound libraries：

Human Endogenous Metabolite Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Cuproptosis Compound Library ReFRAME Related Library Oxidation-Reduction Compound Library Anti-Breast Cancer Compound Library Natural Product Library for HTS NO PAINS Compound Library Antioxidant Compound Library

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Keywords

L-Glutathione reduced 70-18-8 Apoptosis Immunology/Inflammation Metabolism NF-Κb oxidation-reduction Reactive Oxygen Species Ferroptosis Endogenous Metabolite Glutathione reductase Inhibitor inhibit GSH r-L-Glutamyl-L-cysteinyl-glycine LGlutathione reduced gamma-L-Glutamyl-L-cysteinyl-glycine L Glutathione reduced Isethion Glutathione γ-L-Glutamyl-L-cysteinyl-glycine Glutathion Tathion inhibitor

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