Powder: -20°C for 3 years
In solvent: -80°C for 2 years
JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 8-10 weeks | $ 970.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM). |
Targets&IC50 | mGlu5:(EC50)260 nM |
In vivo | JNJ-46778212 increases NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. JNJ-46778212 displays excellent CNS penetration, in oral brain/plasma studies[1]. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory. |
Synonyms | VU 0409551 |
Molecular Weight | 352.36 |
Formula | C20H17FN2O3 |
CAS No. | 1363281-27-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 125 mg/mL (354.75 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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JNJ-46778212 1363281-27-9 Neuroscience GluR JNJ 46778212 VU 0409551 JNJ46778212 Inhibitor inhibitor inhibit