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JNJ-46778212

Catalog No. T15619 CAS 1363281-27-9

Synonyms: VU 0409551

JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

JNJ-46778212, CAS 1363281-27-9

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 970.00
50 mg	8-10 weeks	$ 1,980.00
100 mg	8-10 weeks	$ 2,500.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260 nM).
Targets&IC50	mGlu5:(EC50)260 nM
In vivo	JNJ-46778212 increases NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. JNJ-46778212 displays excellent CNS penetration, in oral brain/plasma studies[1]. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.

Synonyms	VU 0409551
Molecular Weight	352.36
Formula	C20H17FN2O3
CAS No.	1363281-27-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (354.75 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Conde-Ceide S, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20.

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ABP688 MNI 137 AMN082 M77976 JNJ-46778212 gamma-DGG VU0652835 Pomaglumetad methionil

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Keywords

JNJ-46778212 1363281-27-9 Neuroscience GluR JNJ 46778212 VU 0409551 JNJ46778212 Inhibitor inhibitor inhibit

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