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JNJ-46778212
🥰Excellent
Catalog No. T15619Cas No. 1363281-27-9
Alias VU 0409551
JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.
JNJ-46778212
🥰Excellent
Purity: 99.24%
Catalog No. T15619Alias VU 0409551Cas No. 1363281-27-9
JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $56 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $213 | In Stock | |
| 50 mg | $363 | In Stock | |
| 100 mg | $582 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $62 | In Stock |
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Purity:99.24%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ-46778212 (VU 0409551) is a potent and selective mGlu5 allosteric modulator (EC50: 260 nM) used for neurodissection studies. |
| Targets&IC50 | mGlu5:260 nM (EC50) |
| In vivo | JNJ-46778212 exhibits dose-dependent antipsychotic-like activity in rats (3-56.6 mg/kg, po) and reverses AHL[1]. |
| Alias | VU 0409551 |
| Molecular Weight | 352.36 |
| Formula | C20H17FN2O3 |
| Cas No. | 1363281-27-9 |
| Smiles | Fc1ccc(cc1)C(=O)N1CCc2nc(COc3ccccc3)oc2C1 |
| Relative Density. | 1.308 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (227.04 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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