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JH-RE-06

🥰Excellent
Catalog No. T15611Cas No. 1361227-90-8

JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.

JH-RE-06

JH-RE-06

🥰Excellent
Purity: 99.29%
Catalog No. T15611Cas No. 1361227-90-8
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$89In Stock
10 mg$163In Stock
25 mg$372In Stock
50 mg$653In Stock
100 mg$1,160In Stock
1 mL x 10 mM (in DMSO)$92In Stock
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Purity:99.29%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.
Targets&IC50
Rev1-Rev7:0.42 μM (Kd), Rev1-Rev7:0.78 μM (IC50)
In vitro
JH-RE-06 unexpectedly causes dimerization of the REV1 CTD at its REV7-binding surface. It also blocks the REV1-REV7 interaction.
In vivo
In mice, co-administration of JH-RE-06 with cisplatin inhibits the growth of xenograft human melanomas. JH-RE-06 suppresses mutagenic TLS and increases cisplatin-induced toxicity in cultured human and mouse cell lines [1].
Chemical Properties
Molecular Weight468.72
FormulaC20H16Cl3N3O4
Cas No.1361227-90-8
SmilesCC(C)CC(=O)c1c(Nc2ccc(Cl)cc2Cl)[nH]c2c(Cl)ccc([N+]([O-])=O)c2c1=O
Relative Density.1.503 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mg/mL (10.67 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1335 mL10.6673 mL21.3347 mL106.6735 mL
5 mM0.4267 mL2.1335 mL4.2669 mL21.3347 mL
10 mM0.2133 mL1.0667 mL2.1335 mL10.6673 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

RNASynthesisRNA SynthesisREV1-REV7JH-RE-06JHRE06JH RE 06InhibitorinhibitDNASynthesisDNA/RNA SynthesisDNA Synthesis
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