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Izonsteride

Catalog No. T27643 CAS 176975-26-1

Synonyms: LY-320236, LY320236, UNII-A5E8C36F34

Izonsteride (LY320236) is a selective and potent 5alpha reductase inhibitor with dual action on the type I and type II isoforms of the enzyme.Izonsteride is used in the treatment of oncology and genitourinary disorders, and may be used in the study of prostate cancer.

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Izonsteride, CAS 176975-26-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 160.00
5 mg	In stock	$ 400.00
10 mg	In stock	$ 600.00
25 mg	In stock	$ 959.00
50 mg	In stock	$ 1,280.00
100 mg	In stock	$ 1,750.00

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Purity: 99.55%

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Description

In vitro

LY320236 is a benzoquinolinone (BQ) that inhibits 5alpha-R activity in human scalp skin (Ki(typeI)=28.7+/-1.87 nM) and prostatic homogenates (Ki(typeII)=10.6+/-4.5 nM). Lineweaver-Burk, Dixon, and non-linear analysis methods were used to evaluate the kinetics of 5alpha-R inhibition by LY320236. Non-linear modeling of experimental data evaluated V(max) in the presence or absence of LY320236. Experimental data modeled to the following equation 1v=+ fixing the In0c value equal to 1.0 or 0 are consistent with non-competitive or competitive inhibition, respectively. LY320236 is a competitive inhibitor of type I 5alpha-R (In0c=0, Ki=3.39+/-0.38, RMSE = 1.300) and a non-competitive inhibitor of type II 5alpha-R (In0c=1, Ki=29. 7+/-3.4, RMSE = 0.0592). These data are in agreement with the linear transformation of the data using Lineweaver-Burk and Dixon analyses. These enzyme kinetic data support the contention that the BQ LY320236 is a potent dual inhibitor with differing modes of activity against the two known human 5-alpha-reductase isozymes. LY320236 represents a class of non-steroidal 5alpha-R inhibitors with potential therapeutic utility in treating a variety of androgen-dependent disorders.[1]

Synonyms	LY-320236, LY320236, UNII-A5E8C36F34
Molecular Weight	422.61
Formula	C24H26N2OS2
CAS No.	176975-26-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. McNulty AM, et al. Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase. J Steroid Biochem Mol Biol. 2000;72(1-2):13-21. 2. Eisenberger MA, et al. Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible mechanism of action. Urology. 2004;63(1):114-119. 3. Titus M A, et al. 5α-reductase isozymes in castration-recurrent prostate cancer. Androgen Action in Prostate Cancer. 2009: 175-185.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

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Keywords

Izonsteride 176975-26-1 Endocrinology/Hormones Metabolism Reductase LY-320236 LY320236 LY 320236 UNII-A5E8C36F34 inhibitor inhibit

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