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Ispronicline

Name: Ispronicline
Brand: TargetMol
SKU: T27636
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T27636Cas No. 252870-53-4

Alias TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480

Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.

Ispronicline

🥰Excellent

Purity: 99.16%

Catalog No. T27636Alias TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480Cas No. 252870-53-4

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$60	In Stock
10 mg	$89	In Stock
25 mg	$156	In Stock
50 mg	$222	In Stock
100 mg	$328	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.16%

ee:98.18%

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COA CSFC HNMR ORP LCMS

Product Introduction

Bioactivity

Description	Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.
In vivo	In rats, the subcutaneous administration of Ispronicline (10-20 mg/kg) leads to the induction of c-Fos expression in specific regions of the forebrain[1]. The pharmacokinetics of Ispronicline, characterized by a half-life of 2 hours in rats, contrasts with the sustained enhancement of working memory, lasting from 18 hours to 2 days[2].
Synonyms	TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480

Chemical Properties

Molecular Weight	234.34
Formula	C₁₄H₂₂N₂O
Cas No.	252870-53-4
Smiles	CN[C@@H](C)C\C=C\c1cncc(OC(C)C)c1
Relative Density.	0.977 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (213.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2673 mL	21.3365 mL	42.6730 mL	213.3652 mL
5 mM	0.8535 mL	4.2673 mL	8.5346 mL	42.6730 mL
10 mM	0.4267 mL	2.1337 mL	4.2673 mL	21.3365 mL
20 mM	0.2134 mL	1.0668 mL	2.1337 mL	10.6683 mL
50 mM	0.0853 mL	0.4267 mL	0.8535 mL	4.2673 mL
100 mM	0.0427 mL	0.2134 mL	0.4267 mL	2.1337 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc