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Ispronicline

Catalog No. T27636 CAS 252870-53-4

Synonyms: AZD-3480, RJR-1734, AZD 3480, TC 1734, AZD3480, TC-01734, TC-1734-112

Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.

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Ispronicline, CAS 252870-53-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 72.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 169.00
50 mg	In stock	$ 248.00
100 mg	In stock	$ 368.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 96.54%

ee: 98.18%

Purity: 96.49%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.
In vivo	In rats, the subcutaneous administration of Ispronicline (10-20 mg/kg) leads to the induction of c-Fos expression in specific regions of the forebrain[1]. The pharmacokinetics of Ispronicline, characterized by a half-life of 2 hours in rats, contrasts with the sustained enhancement of working memory, lasting from 18 hours to 2 days[2].

Synonyms	AZD-3480, RJR-1734, AZD 3480, TC 1734, AZD3480, TC-01734, TC-1734-112
Molecular Weight	234.34
Formula	C14H22N2O
CAS No.	252870-53-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (213.37 mM), Sonication is recommended.

References and Literature

1. Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515(1):7-11. 2. Gabrielsson J, Peletier LA. Dose-response-time data analysis involving nonlinear dynamics, feedback and delay. Eur J Pharm Sci. 2014 Aug 1;59:36-48. doi: 10.1016/j.ejps.2014.04.007. PubMed PMID: 24751673. 3. Levin ED. Nicotinic attention-deficit/hyperactivity disorder treatment. Biol Psychiatry. 2014 Feb 1;75(3):174. doi: 10.1016/j.biopsych.2013.11.024. PubMed PMID: 24370349. 4. Potter AS, Dunbar G, Mazzulla E, Hosford D, Newhouse PA. AZD3480, a novel nicotinic receptor agonist, for the treatment of attention-deficit/hyperactivity disorder in adults. Biol Psychiatry. 2014 Feb 1;75(3):207-14. doi: 10.1016/j.biopsych.2013.06.002. PubMed PMID: 23856296.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ispronicline 252870-53-4 Neuroscience AChR TC01734 AZD-3480 RJR-1734 AZD 3480 TC 1734 AZD3480 TC-01734 TC-1734-112 TC-1734 TC1734 TC 01734 inhibitor inhibit

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