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Ispronicline

Name: Ispronicline
Brand: TargetMol
SKU: T27636
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27636Cas No. 252870-53-4

Alias TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480

Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.

Ispronicline

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Purity: 99.16%

Catalog No. T27636Alias TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480Cas No. 252870-53-4

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$36	-	In Stock
10 mg	$53	-	In Stock
25 mg	$94	-	In Stock
50 mg	$133	-	In Stock
100 mg	$197	-	In Stock
1 mL x 10 mM (in DMSO)	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.16%

ee:98.18%

Appearance:Oil

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COA LCMS CSFC HNMR ORP

Product Introduction

Bioactivity

Description	Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effects.Ispronicline has a high affinity for the α4β2 nAChR with a Ki= 11 nM.
In vivo	In rats, the subcutaneous administration of Ispronicline (10-20 mg/kg) leads to the induction of c-Fos expression in specific regions of the forebrain[1]. The pharmacokinetics of Ispronicline, characterized by a half-life of 2 hours in rats, contrasts with the sustained enhancement of working memory, lasting from 18 hours to 2 days[2].
Synonyms	TC-01734, TC 1734, RJR-1734, AZD-3480, AZD3480, AZD 3480

Chemical Properties

Molecular Weight	234.34
Formula	C₁₄H₂₂N₂O
Cas No.	252870-53-4
Smiles	CN[C@@H](C)C\C=C\c1cncc(OC(C)C)c1
Relative Density.	0.977 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (213.37 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.53 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2673 mL	21.3365 mL	42.6730 mL	213.3652 mL
5 mM	0.8535 mL	4.2673 mL	8.5346 mL	42.6730 mL
10 mM	0.4267 mL	2.1337 mL	4.2673 mL	21.3365 mL
20 mM	0.2134 mL	1.0668 mL	2.1337 mL	10.6683 mL
50 mM	0.0853 mL	0.4267 mL	0.8535 mL	4.2673 mL
100 mM	0.0427 mL	0.2134 mL	0.4267 mL	2.1337 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc