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Isovalerylshikonin

Catalog No. TN2447 CAS 76549-35-4

Isovalerylshikonin is a natural product from Onosma heterophylla and Arnebia euchroma.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Isovalerylshikonin, CAS 76549-35-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 229.00
5 mg	In stock	$ 577.00
10 mg	In stock	$ 826.00

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Biological Description

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Description	Isovalerylshikonin is a natural product from Onosma heterophylla and Arnebia euchroma.
Targets&IC50	S. aureus:16 mg/L(MIC)
In vitro	Isovalerylshikonin exhibited marginal antibacterial activity against drug-resistant Staphylococcus aureus RN4220, with an MIC of 16 mg/L[1].
In vivo	A peritonitis/sepsis model was employed to test the in vivo synergistic activity of IVS and STM. IVS synergistically decreased the bacteria count with STM in peritoneal, spleen and liver, and increased mouse survival with STM in 7 days. The acute toxicity of IVS was tested, and the LD50 of IVS with a single exposure was 2.584 g/kg in mice. Overall, isovalerylshikonin, a low toxicity resistance-modifying agent, exhibited synergistic antibacterial activities in vitro and in vivo against drug-resistant S. aureus. The effects were mediated by suppression of msrA mRNA expression and bacterial efflux[1].
Source	Natural Products > Boraginaceae > Arnebia

Molecular Weight	372.41
Formula	C21H24O6
CAS No.	76549-35-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jian-Ming, Shi-Chang, Sun, et al. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus.[J]. International journal of antimicrobial agents, 2018.

Related compound libraries

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Isovalerylshikonin 76549-35-4 Microbiology/Virology Antibacterial inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.