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Sodium 4-aminosalicylate dihydrate

Catalog No. T0020 CAS 6018-19-5

Synonyms: Sodium 4-Aminosalicylate, 4-Amino-salicylic acid sodium salt

Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.

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Sodium 4-aminosalicylate dihydrate Chemical Structure

Sodium 4-aminosalicylate dihydrate, CAS 6018-19-5

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1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 99.78%

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Storage & Solubility Information

Description	Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.
In vitro	Following local perfusion with 7.5 mg/mL of 4-aminosalicylate, N-acetyl-5-aminosalicylic acid was detected in the intestines of anesthetized rats.
In vivo	4-Aminosalicylate exhibits effective DPPH radical scavenging activity and rapidly neutralizes hydroperoxyl radicals in aqueous solutions, displaying a concentration-dependent cycle similar to that of Trolox or cysteine, indicative of chain-breaking antioxidant activity. At 0.65 mM, 4-aminosalicylate attenuates the lethal effects of superoxide radicals or hydrogen peroxide on Chinese hamster ovary cells. In cultured mouse peritoneal macrophages, aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner, and at 5 mM, it enhances protein kinase C activation of PLD. Post-treatment with 4-aminosalicylate (20 mM) results in a 260% increase in inositol 1,4,5-trisphosphate levels in macrophages. Furthermore, in isolated colonic mucosal cells, 4-aminosalicylate (0.1 mM) dose-dependently reduces the synthesis of LTB4, thereby decreasing the LTB4/PGE2 ratio.

Synonyms	Sodium 4-Aminosalicylate, 4-Amino-salicylic acid sodium salt
Molecular Weight	211.15
Formula	C7H6NNaO3·2H2O
CAS No.	6018-19-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 198.9 mM

DMSO: 198.9 mM

References and Literature

1. Dinis TC, et al. Arch Biochem Biophys, 1994, 315(1), 161-169.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Transcription Factor-Targeted Compound Library Clinical Compound Library Antibiotics Library Anti-Prostate Cancer Compound Library Immunology/Inflammation Compound Library HIF-1 Signaling Pathway Compound Library

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Keywords

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