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Isoescin IB

Catalog No. TN1777 CAS 219944-46-4

Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

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Isoescin IB, CAS 219944-46-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 280.00
10 mg	In stock	$ 415.00
25 mg	In stock	$ 688.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 498.00

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Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.
In vivo	Five groups of Wistar rats (n=6 per group) were treated with either an intravenous (IV) dose (2.78mg/kg) of sodium escinate (corresponding to 0.5mg/kg of Escin IB and 0.5mg/kg of Isoescin IB), an IV dose (0.5mg/kg) and an oral dose (4mg/kg) of pure Escin IB or Isoescin IB. The administration of sodium escinate, which contains the two isomers, gave rise to higher terminal phase half-life (t1/2) and mean residence time (MRT) values for both Escin IB and Isoescin IB compared to the corresponding compounds administered alone. The absorption of Escin IB and Isoescin IB was very poor, with the oral bioavailability (F) values of <2% observed for both compounds. The two compounds were found to isomerize in vivo, wherein the conversion of Escin IB to Isoescin IB was much easier than that of Isoescin IB to Escin IB[1].
Source	Natural Products > Hippocastanaceae > Aesculus

Molecular Weight	1131.26
Formula	C55H86O24
CAS No.	219944-46-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (88.40 mM)

References and Literature

1. Wu XJ, et al. Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats.J Ethnopharmacol. 2014 Feb 3;151(2):839-45.

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Keywords

Isoescin IB 219944-46-4 Others Escin inhibit Inhibitor Escin IB inhibitor

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