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Irtemazole

Catalog No. T32194 CAS 129369-64-8

Synonyms: R60844, R-60844, R 60844

Irtemazole (R 60844) is a novel uricosuric substance that is valuable in the treatment of hyperuricemia and gout.

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Irtemazole, CAS 129369-64-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 112.00
5 mg	In stock	$ 260.00
10 mg	In stock	$ 390.00
25 mg	In stock	$ 653.00
50 mg	In stock	$ 928.00
100 mg	In stock	$ 1,260.00
500 mg	In stock	$ 2,530.00

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Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Irtemazole (R 60844) is a novel uricosuric substance that is valuable in the treatment of hyperuricemia and gout.

In vivo

Irtemazole (12.5 to 50 mg; oral; 6 patients) caused a maximal decrease in plasma uric acid (after 8 to 12 h) of 46.5%. The uricosuric effect began during the first 60 min after drug administration and it lasted for 7 to 24 h. Renal uric acid excretion returned to its base line value after 8 to 16 h and uric acid clearance after 10.0 to 12.0 h. Doses of irtemazole between 12.5 and 37.5 mg produced a dose-related rise in the uricosuric effect. There was no essential difference between the uricosuric effect of 37.5 mg and 50 mg irtemazole. The D50 dose (that producing a half-maximal effect) was between 16.3 mg and 34.2 mg, (average 24.7 mg). The value of irtemazole in the management of hyperuricaemia and gout remains to be determined.[2]

Synonyms	R60844, R-60844, R 60844
Molecular Weight	288.35
Formula	C18H16N4
CAS No.	129369-64-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (190.74 mM)

References and Literature

1. Kamilli I, et al. Pharmacokinetics and pharmacodynamics of different doses of Irtemazole in repeated application. Z Rheumatol. 1991;50(1):23-28. 2. Gresser U, et al. Uricosuric effect of different doses of irtemazole in normouricaemic subjects. Eur J Clin Pharmacol. 1990;38(5):489-491. 3. Kamilli I, et al. Uricosuric effect of irtemazole in hyperuricemic patients without and with renal insufficiency. Z Rheumatol. 1989;48(6):307-312. 4. Gresser U, et al. Rapid onset of uricosuria after oral administration of irtemazole, an uricosuric substance. Klin Wochenschr. 1989;67(20):1058-1060. 5. Gresser U,et al. Uricosuric effect of irtemazole in healthy subjects. Klin Wochenschr. 1989;67(19):971-975.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Irtemazole 129369-64-8 Others R60844 R-60844 R 60844 inhibitor inhibit

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