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Irilone

Catalog No. TN6524 CAS 41653-81-0

Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiated the effect of progesterone in both endometrial and ovarian cancer cell lines, it protected dopaminergic neurons against LPS-induced injury through inhibition of microglia activation and proinflammatory factors generation.

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Irilone, CAS 41653-81-0

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5 mg	Inquiry	$ 678.00
1 mL * 10 mM (in DMSO)	Inquiry	$ 809.00

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Description	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiated the effect of progesterone in both endometrial and ovarian cancer cell lines, it protected dopaminergic neurons against LPS-induced injury through inhibition of microglia activation and proinflammatory factors generation.
In vitro	The use of botanical dietary supplements is becoming increasingly popular for the alleviation of hormonal-based conditions such as hot flashes, premenstrual syndrome, and fertility. Estrogen and progesterone receptors (ER and PR) play an essential role in these processes. However, despite the fact that many therapies used to alleviate gynecological conditions act through PR-mediated mechanisms, few studies have investigated or identified any herbal natural product components that act on this receptor. METHODS AND RESULTS:In the current study, we used a progesterone response element (PRE)-luciferase (Luc) reporter assay to identify four phytoprogestins present in a standardized red clover (Trifolium pratense) extract. We found that the component Irilone (1) potentiated the effect of progesterone in both endometrial and ovarian cancer cell lines. In these cancers, progesterone action is generally associated with positive outcomes; thus the potentiating effect of 1 may provide entirely new strategies for enhancing progesterone signaling as a means of mitigating conditions such as fibroids and endometriosis. Formononetin (3) and biochanin A (4) exhibited mixed agonist activity, while prunetin (2) acted only as an antagonist. CONCLUSIONS: Collectively, these results suggest that the effects of red clover extract repeatedly observed in cultured cells and the inverse correlation between risk of various cancers and flavonoid intake may be due, in part, to altered progesterone signaling.
Source	Natural Products > Fabaceae > Trifolium

Molecular Weight	298.25
Formula	C16H10O6
CAS No.	41653-81-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Irilone from Red Clover (Trifolium pratense) Potentiates Progesterone Signaling. J Nat Prod. 2018 Sep 28;81(9):1962-1967.

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Irilone 41653-81-0 inhibitor inhibit

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