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Iberin

Catalog No. T15544 CAS 505-44-2

Synonyms: NSC 321801

Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane.

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Iberin, CAS 505-44-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 59.00
5 mg	In stock	$ 136.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 328.00
50 mg	In stock	$ 491.00
100 mg	In stock	$ 716.00
500 mg	In stock	$ 1,480.00

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Purity: 99.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane.
Targets&IC50	Cell survival:2.3 μM
In vitro	Iberin inhibits neuroblastoma cell growth in a dose- and time-dependent manner and inhibits the expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. Iberin increases the apoptotic cell death and activates caspase-9, caspase-3, and PARP[2].
In vivo	Iberin enhances tissue levels of the phase II detoxification enzymes quinone reductase and GST in a variety of rat tissues[5].

Synonyms	NSC 321801
Molecular Weight	163.26
Formula	C5H9NOS2
CAS No.	505-44-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 9.0 mg/mL (55.1 mM), Sonication is recommended.

DMSO: 279.0 mg/mL (1708.9 mM）

References and Literature

1. Jakubikova J, et al. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3375-86. 2. Jadhav U, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. 3. Jadhav U, et al. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007 Feb;103(2):247-51. 4. Jakobsen TH, et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorumsensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-21. 5. Munday R, et al. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004 Apr 7;52(7):1867-71.

Related compound libraries

This product is contained In the following compound libraries：

Selected Plant-Sourced Compound Library Bioactive Compound Library Natural Product Library for HTS Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Iberin 505-44-2 Metabolism Endogenous Metabolite NSC321801 NSC 321801 NSC-321801 inhibitor inhibit

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